![Dr Siang Boon Koh](https://research-information.bris.ac.uk/ws/files/306282866/Photo.jpg)
Dr Siang Boon Koh
BSc (Pharm), PhD
Current positions
Contact
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Research interests
The Koh Laboratory is interested in exploring and exploiting molecular aberrations in cancer. Through collaborative use of omics profiling, imaging, molecular biology, pharmacology and computational approaches, we study how deregulated biological pathways, such as the DNA Damage Response and RAS signalling network, mediate tumour proliferation and progression. We leverage these mechanistic insights to identify actionable cancer-specific vulnerabilities. Our goal is to develop selective, synergistic treatment strategies that enable maximal tumour-cell killing and minimal host toxicity.
Enquiries from prospective graduate students and postdoctoral researchers are welcome.
Projects and supervisions
Thesis supervisions
Publications
Recent publications
20/05/2023Regulation of RNA methylation by therapy treatment, promotes tumor survival
bioRxiv
The expanding role of WEE1
Cellular Signalling
Immune activation and evolution through chemotherapy plus checkpoint blockade in triple-negative breast cancer
Cancer Cell
Prediction and identification of synergistic compound combinations against pancreatic cancer cells
iScience
RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer
Clinical Cancer Research